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By Levels, Committee On Acute Exposure Guideline

ISBN-10: 0309283086

ISBN-13: 9780309283083

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Additional info for Acute exposure guideline levels for selected airborne chemicals : volume 14.

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On the basis of tests with human volunteers, Ketchum et al. 5 mg-min/m3). 4. 1. Metabolism and Disposition BZ hydrolyzes in aqueous environments to benzilic acid and 3quinuclidinol. It is reportedly excreted primarily in the urine (Byrd et al. 1992). In rats, about 3% of a dose (route not specified) is excreted unchanged in the urine. 2. Mechanism of Toxicity BZ is an anticholinergic agent similar in its pharmacologic action to atropine and scopolamine although more potent than both (Ketchum and Sidell 1997).

Snyder. 1974. Muscarinic cholinergic receptor binding in the longitudinal muscle of the guinea pig ileum with [3H] quinuclidinyl benzilate. Mol. Pharmacol. 10(6):861-867. 34 Acute Exposure Guideline Levels APPENDIX A DERIVATION OF AEGL VALUES FOR AGENT BZ Derivation of AEGL-1 Values Although exposures to BZ resulting in no apparent effects in animals were available, the experiments could not assess possible cognitive and behavioral effects characteristic of BZ that are relevant to humans. Human data on BZ that define no-effect levels or that are consistent with the AEGL-1 definition were not available.

AEGL Values and Toxicity End Points AEGL values for BZ are presented in Table 1-10. The available data do not allow for assessing a minimal-effect threshold appropriate for developing AEGL-1 values. For AEGL-2 values, the point of departure was selected on the basis of preventing cognitive, behavioral, or physiologic effects. Cognitive and behavioral effects resulting from the anticholinergic activity of BZ are the most relevant effects (incapacitation) regarding human exposure to this chemical.

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