By James C. Fishbein (Eds.)
Advances in Molecular Toxicology positive factors the newest advances in all the subspecialties of the large sector of molecular toxicology. Toxicology is the research of toxins, and this sequence info the examine of the molecular foundation in which an enormous array of brokers encountered within the human atmosphere and produced through the human physique itself appear themselves as pollution. no longer strictly constrained to documenting those examples, the sequence is usually fascinated by the complicated net of chemical and organic occasions that provide upward push to toxin-induced signs and disorder. the recent applied sciences which are being harnessed to investigate and comprehend those occasions may also be reviewed by means of best staff within the box. Advances in Molecular Toxicology will file development in all facets of those quickly evolving molecular elements of toxicology with a view towards designated elucidation of either growth at the molecular point and on advances in technological methods hired. * state of the art stories via best staff within the self-discipline. * In-depth dissection of molecular elements of curiosity to a vast diversity of scientists, physicians and any scholar within the allied disciplines. * cutting edge purposes of technological techniques in chemistry, biochemistry and molecular drugs.
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An excellent, state of the art exploration of the dramatic upward thrust of allergic and autoimmune illnesses and the debatable, most likely groundbreaking treatments that scientists are constructing to right those issues
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Shen, S. Kawasaki, K. Q. J. I. Rennard, Prostaglandin E2 protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP2 receptor activation, J. Cell Physiol. 210 (2007) 99–110.  A. Kawabata, S. Kubo, T. Ishiki, N. Kawao, F. Sekiguchi, R. D. Hollenberg, T. Kanke, N. Saito, Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: Signal transduction mechanisms and distinct agonist sensitivity, J. Pharmacol. Exp. Ther. 311 (2004) 402–410.
D. G. A. D. Leikauf, Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation, Am. J. Respir. Crit. Care Med. 171 (2005) 305–314. S. Deshmukh, C. M. Case, M. C. D. R. Korfhagen, M. A. T. D. Leikauf, Invited Review                 33 Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production, Am. J. Respir. Cell Mol. Biol. 38 (2008) 446–454. A. C. Burcham, Genome-wide transcriptional responses to acrolein, Chem.
Exp. Ther. 315 (2005) 576– 589.  S. A. Peebles, S. T. M. Dubinett, The role of PPAR in the cyclooxygenase pathway in lung cancer, PPAR Res. 2008 (2008) 790568. M. Lee, J. A. Peebles, S. T. M. Dubinett, Inflammation in lung carcinogenesis: New targets for lung cancer chemoprevention and treatment, Crit. Rev. Oncol. Hematol. 66 (2008) 208–217. C H A P T E R 2 Heterocyclic Aromatic Amines Potential Human Carcinogens Robert J. TureskyÃ Contents 1. 1. 2. 3. Estimates of HAAs in cooked meat, poultry, and fish 2.
Advances in Molecular Toxicology by James C. Fishbein (Eds.)